Dynamic Nature of Cleavage Bodies and Their Spatial Relationship to DDX1 Bodies, Cajal Bodies, and Gems
نویسندگان
چکیده
منابع مشابه
Dynamic nature of cleavage bodies and their spatial relationship to DDX1 bodies, Cajal bodies, and gems.
DDX1 bodies, cleavage bodies, Cajal bodies (CBs), and gems are nuclear suborganelles that contain factors involved in RNA transcription and/or processing. Although all four nuclear bodies can exist as distinct entities, they often colocalize or overlap with each other. To better understand the relationship between these four nuclear bodies, we examined their spatial distribution as a function o...
متن کاملCajal bodies
What are they? Cajal bodies are nuclear suborganelles, typically 0.5 μm in diameter, discovered in 1903 by Santiago Ramón y Cajal. They are dynamic structures involved in the biogenesis of small ribonucleoproteins (RNPs). Cajal bodies contain the highest concentration of small RNPs in the nucleoplasm, as well as a host of other protein factors involved in diverse processes. They are not major s...
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A dystroglycan ligand in the brain ystroglycans are present on the surfaces of cells throughout the body, anchoring cells in the matrix that surrounds them. This function is conspicuously important for muscle cells. Defects in the protein dystrophin, which is D connected to dystroglycan, destabilize the connection of muscle cells to their matrix and cause muscular dystrophy. Dystroglycans are a...
متن کاملInteractions of U2 gene loci and their nuclear transcripts with Cajal (coiled) bodies: evidence for PreU2 within Cajal bodies.
The Cajal (coiled) body (CB) is a structure enriched in proteins involved in mRNA, rRNA, and snRNA metabolism. CBs have been shown to interact with specific histone and snRNA gene loci. To examine the potential role of CBs in U2 snRNA metabolism, we used a variety of genomic and oligonucleotide probes to visualize in situ newly synthesized U2 snRNA relative to U2 loci and CBs. Results demonstra...
متن کاملCajal bodies are linked to genome conformation.
The mechanisms underlying nuclear body (NB) formation and their contribution to genome function are unknown. Here we examined the non-random positioning of Cajal bodies (CBs), major NBs involved in spliceosomal snRNP assembly and their role in genome organization. CBs are predominantly located at the periphery of chromosome territories at a multi-chromosome interface. Genome-wide chromosome con...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2006
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e05-08-0768